The laboratory of Dr. Andrea Bonetto, Associate Professor in the Department of Pathology, is seeking two ambitious and talented individuals to take part in basic and translational research aimed at investigating the musculoskeletal consequences of cancer and its treatments, with a special focus on the inter-organ complications affecting muscle, bone and liver. These studies are funded by multiple sources, including NIH and American Cancer Society. The laboratory is also interested in unraveling the molecular causes responsible for the muscle and bone abnormalities resulting from metabolic dysfunctions and aging. The laboratory uses state-of-the-art technologies and tissue-specific mutant mouse models to examine the molecular mechanisms that trigger cancer-induced musculoskeletal defects. The projects are highly collaborative and multidisciplinary with excellent opportunities for advanced training and scientific development. Interested candidates will have extensive experience in skeletal muscle physiology, a background in cancer biology, and experience characterizing mouse models, as also evidenced by their publication records. A background in bone biology or willingness to develop an interest in skeletal physiology and muscle-bone crosstalk, as well as a basic knowledge in neuromuscular physiology are preferred. The candidates will join a dynamic and fast-paced research environment and will be responsible for the development of novel research methods, will conduct experiments using in vitro and in vivo approaches, will perform project planning, data interpretation, authorship of presentations and publications, lab management, and training of personnel. The PI is committed to supporting the candidate’s career development and research progress, including fostering and facilitating grant submissions, attending and presenting at scientific meetings, and exploring new project areas and collaborations.
Cancer Cachexia, cancer-induced musculoskeletal complications
Examples of Work Performed
The duties and responsibilities of the positions include, but are not limited to: cell culture utilizing skeletal muscle, bone and cancer cells; mouse survival surgeries for tumor implantation and resection; in vivo dosing with experimental anti-cachexia compounds and anti-cancer drugs; body composition analysis and imaging (e.g., DXA, in vivo and ex vivo microCT); in vivo and ex vivo assessment of skeletal muscle function; molecular techniques including western blotting, shRNA/CRISPR, qPCR, protein/RNA/DNA extraction; basic histological techniques, including immunofluorescence, immunohistochemistry, cell imaging of muscle and bone specimens; writing of scientific manuscripts and grants; training of lab personnel at all levels; preparing laboratory data for discussion and presentation, attending and presenting at laboratory meetings and research conferences.
The employee will report to the PI, Dr. Andrea Bonetto.
This description is a summary only and is describing the general level of work being performed, it is not intended to be all-inclusive. The duties of this position may change from time to time and/or based on business need. We reserve the right to add or delete duties and responsibilities at the discretion of the supervisor and/or hiring authority.
Diversity and Equity:
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Applicants must meet minimum qualifications at the time of hire.
Special Instructions to Applicants: Review of applications will begin immediately and will continue until the position is filled. Applications are accepted electronically ONLY at www.cu.edu/cu-careers. Refer to requisition number: 26799. Application Materials Required: Cover Letter, Resume/CV, List of References Application Materials Instructions: Required Application Materials: To apply, please visit: http://www.cu.edu/cu-careers and attach: 1. A letter of application which specifically addresses the job requirements and outlines qualifications 2. A current CV/resume 3. List of five professional references (we will notify you prior to contacting both on and off-list references) Please be advised that the University does check references as part of the employment process. Please do not submit any of your application material (via email) to the job posting contact.