Open positions at Dyne Therapeutics

    Company Overview:

    Dyne Therapeutics is pioneering life-transforming therapies for patients with serious muscle diseases. The company’s FORCE™ platform delivers oligonucleotides and other molecules to skeletal, cardiac and smooth muscle with unprecedented precision to restore muscle health. Dyne is advancing treatments for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Dyne was founded by Atlas Venture and is headquartered in Waltham, Mass. For more information, please visit www.dyne-tx.com.

    Senior Research Associate/Associate Scientist – In vivo Biology

    Role: Dyne is seeking a talented and highly motivated Senior Research Associate/Associate Scientist in the in vivo biology group to support our drug discovery programs. This member will collaborate closely with cross-functional groups, execute established biomarker assays using a variety of readout technologies.

    The successful candidate will be ambitious, motivated, an energetic self-starter, and enjoy working in a fast-paced environment.  We offer a competitive salary with benefits and opportunities for learning and advancement in an exciting start-up environment.

    Primary Responsibilities Include:

    • Execute research plans for in vivo studies.
    • Analyze data and communicate findings to team members and management.
    • Contribute to critical discussion of experimental design and assay development.

    Education and Skills Requirements:

    • BS/MS or equivalent in a biological discipline and 1-3 years of hands-on academic/ industry experience.
    • Experience required in one or more of the following:
      • Oligonucleotide therapeutics
      • Antibody therapeutics
      • Muscle biology
    • Experience with molecular biology techniques including, but not limited to:
      • Nucleic acid isolation extraction for gene expression analysis.
      • Protein isolation, performing Western blots and ELISA.
      • Familiarity with histological protocols (tissue-fixation, embedding, sectioning, staining, IF, IHC) is beneficial.
    • Experience with handling in vivo samples is desirable.
    • Have excellent organizational skills, be detailed-oriented, and the ability to support others in a faced-paced environment.
    • Ability to effectively communicate ideas and document research.
    • Experienced in software applications (Prism, Excel, PowerPoint).

    LOCATION: Waltham, MA, USA
    APPLY BEFORE: Submission dates current through July 31, 2020; position start date negotiable
    TO APPLY: Please send resumes, and any other supporting materials, to: Careers@dyne-tx.com

    Scientist – Cell Biology

    Role: We are seeking an experienced and highly motivated Scientist to join our Cell Biology team working on multiple programs. The successful candidate will be involved in all aspects of in vitro biology to evaluate efficacy, pharmacodynamics, pharmacokinetics, and mechanism of action of antibody-drug conjugates. The successful candidate will also have extensive assay development experience and be able to provide biology insights on new targets and therapeutic hypotheses to guide drug discovery efforts. The ideal candidate will be an innovative and collaborative team player and an ambitious self-starter who enjoys working in a fast-paced team setting. We offer a competitive salary with benefits and an opportunity for learning and advancement in an exciting startup environment.

    Primary Responsibilities Include:

    • Design, execute, and analyze in vitro studies to profile candidates for proof of mechanism and proof of concept.
    • Evaluate and validate in vitro disease model systems for muscle diseases.
    • Hands-on experimental analysis of in vitro studies to drive go/no go data decisions.
    • Utilize resources to design, evaluate, and develop new assays to answer key muscle disease questions to drive programs towards clinical development.
    • Contribute technically and scientifically to the strategy and tactics of multiple projects.
    • Work effectively with other disciplines including biochemistry, in vivo biology, and safety/tox to collectively build the preclinical data package for clinical candidate nomination.
    • Contribute to building a positive, team-oriented culture.

    Education and Skills Requirements:

    • PhD in molecular biology, pharmacology or related life sciences and 1-2 years of hands-on industry experience in at least one of the following:
      • Oligonucleotide therapeutics
      • Antibody therapeutics
      • Muscle biology
    • BSc/MSc with 5 or more years of relevant experience will also be considered.
    • Strong track record of research experience with relevant publications and presentations.
    • Strong hands-on experience working with in vitro models including primary cell culture using molecular techniques including qPCR, ELISA, Luminex, immunohistochemistry, immunofluorescence, in-situ hybridization, Western blot, flow cytometry.
    • Strong written and oral communication skills, organization and multitasking, and working in a highly collaborative and cross-functional research environment.
    • Proven ability to work independently and effectively manage CROs and to facilitate interactions with academic labs to ensure project progression.

    LOCATION: Waltham, MA, USA
    APPLY BEFORE: Submission dates current through July 31, 2020; position start date negotiable
    TO APPLY: Please send resumes, and any other supporting materials, to: Careers@dyne-tx.com

    Director, Head of QA

    Role: The position will be responsible for developing and maintaining phase appropriate quality systems, quality operations related to oversight of the manufacture cGMP supply of antibody drug conjugates and intermediates, as well as applicable GCP and GLP study sites. Depending on the product phase, the Director provides both guidance and active development and management of quality systems in Phase 1 through BLA in preparation for commercial production. This will include development of quality systems covering, but not limited to, coordinating external audits and vendor assurance with contract development and manufacturing organizations (CDMOs), contract test labs (CTLs) and other external suppliers. In addition to this external oversight, this position will require the routine management of GXP quality systems internally.

    Key Responsibilities:

    • Develops QA function and actively manages GMP oversight of API and drug products produced at contract manufacturing sites
    • Develops applicable QA functions and actively manages GCP and GLP oversight both clinical and nonclinical study sites.
    • Ensures Phase appropriate compliance with quality systems, quality procedures, and quality policies
    • Develops, implements, and maintains programs/processes in compliance with cGMP
    • Responsibilities include the final release of cGMP intermediates, conjugated drug substance, drug product, and for all intended markets
    • Responsible for Dyne Inspection Readiness of all internal sites and external vendors
    • Represents company as host of regulatory inspections at applicable contract sites and supports inspections at CMO facilities
    • Works with Process Development and Manufacturing during technology transfer of new and existing processes to CMOs
    • Works with appropriate team members to develop processes to support Dyne’s nonclinical safety (GLP) program
    • Works with appropriate team members to develop processes to support Dyne’s clinical (GCP) program
    • Develops and implements a QA departmental budget
    • Directs all GXP compliance audits as required
    • Oversight and validation of electronic systems used for GXP or regulatory submissions
    • Reviews, approves, and directs implementation of changes to controlled documents and processes

    Professional Experience/Qualifications:

    • A minimum of 15 years in biopharmaceutical QA management. Degree in biology, biochemistry, chemistry or similar preferred
    • Proven experience in QA processes and systems to support biopharmaceutical development
    • Experience work with external vendors required. Experience with bioconjugates or multiple intermediates preferred
    • Experience in leading the Quality function for a biopharmaceutical company and familiarity with GxPs
    • Experience with implementing and managing QA documentation systems
    • Experience with GDPR and acting as company Data Protection Officer (DPO) desirable
    • Excellent interpersonal, organizational, negotiations and communication skills
    • Effective team member than can work collaboratively across all functions
    • Demonstrates strong organizational skills, including the ability to prioritize workload
    • Ability to work well in a deadline-driven environment and capable of supporting multiple programs

    Personal Characteristics:

    • Results oriented: Establishes clear expectations and priorities, sets objectives and effectively applies resources. Sets clear goals and consistently delivers. Flexible and creative problem-solving skills.
    • Strategic Thinking: Can see the big picture, able to constantly think ahead about ways to do things better. Thinks logically, develops and evaluates options, identifies pros and cons. Able to challenge current processes, practices and strategy and uncover alternative approaches, solutions or methods.
    • Communications: Excellent communication and interpersonal skills with success in working across organizational boundaries at all levels to bring together people of diverse backgrounds and skill-sets to create, influence and negotiate win-win solutions.
    • Strong interpersonal skills with the ability to motivate others, influence without authority, and negotiate conflict situations. Highly collaborative team player who fosters open communication and facilitates mutual understanding and cooperation between all stakeholders.
    • Self-directed: Individual who is able to work effectively with limited direction in a complex, fast-paced environment.

    LOCATION: Waltham, MA, USA
    APPLY BEFORE: Submission dates current through July 31, 2020; position start date negotiable
    TO APPLY: Please send resumes, and any other supporting materials, to: Careers@dyne-tx.com