We are seeking to appoint a highly motivated and talented cell biologist with the experimental and analytical expertise required to conduct neuromuscular translational research.
As an experienced molecular and cell biologist with a background in the neuromuscular field, you will develop, establish, and pursue your research programme.
In addition to your primary role to conduct laboratory research, you will supervise the laboratory work of students, research assistants and postdoctoral fellows affiliated to the Centre.
You will be expected to raise funding for your own research and to carry out collaborative projects with DNC colleagues and their collaborators in partnering academic or industrial institutions and present research findings at seminars and conferences.
You will have experience in muscle biology and sufficient specialist knowledge to develop research projects and methodologies relevant to the field, including, for example, cell culture, manipulation of gene expression (e. g. siRNA, CRISPRi/a, splicing modulation, lentiviral transduction), cell-based assays (fluorescent-based reporters, immunocytochemistry).
Experience working with animal models and/or in genetic therapy or related field is also required.
You will have in-depth knowledge of molecular biology techniques (e.g., design and manipulation of expression constructs, PCR, RT-qPCR, site-directed mutagenesis) as well as biochemical techniques (e.g., western blotting). Experience in single-nuclei RNASeq and/or spatial transcriptomics is desirable. You will be able to independently design, conduct, analyse, and troubleshoot rigorous in vivo and in vitro experiments to drive projects.
Please see further details via application link.
The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. Please see application link for more information.
