We are seeking a highly motivated Postdoctoral Researcher to work on a research project contributing to an innovative therapeutic approach for muscular dystrophies. The project aims to investigate the role of the fusogenic transmembrane proteins Mymk and Mymx in skeletal muscle homeostasis and regeneration, and how their dysregulated expression contributes to impaired muscle regeneration, increased apoptosis, and tissue atrophy in dystrophic conditions, with particular emphasis on LAMA2-related muscular dystrophy (LAMA2-RD). Using both in vitro models (dystrophic satellite cells and myofibers) and in vivo approaches (mouse model of complete Laminin-211 deficiency), the candidate will study the impact of altered Mymk/Mymx expression on cell cycle regulation and apoptosis by fine-tuning their expression at different developmental timepoints.
Duties and Responsibilities:
Required Qualifications/Skills
Desirable Skills
Send CV to Prof. Stefano Previtali ([email protected]) and Dr. Veronica Pini ([email protected]).
https://research.hsr.it/en/institutes/institute-of-experimental-neurology/neuromuscular-repair.html
Our main interest is in preclinical, translational, and clinical research on genetic and inflammatory disorders of peripheral nerve, neuromuscular junctions, and skeletal muscle. We have primary interest in inherited neuropathies (e.g., CMT, HMN), muscular dystrophies (e.g., Duchenne, LAMA2 disease, FSHD), and myositis. Our studies span from development to mechanisms of regeneration, generation of cellular and animal models and, potentially, translation into clinical trials.
