PhD studentship in Neuromuscular disorders: dissecting the molecular mechanisms of muscle damage in Facioscapulohumeral muscular dystrophy (FSHD)

Newcastle University, Faculty Medical Sciences

Are you interested in exploring the molecular and cellular mechanisms active in muscular dystrophies? 

In this project you will work on dissecting the biological pathways leading to skeletal muscle degeneration in a prevalent and currently untreatable form of muscular dystrophy called Facioscapulohumeral muscular dystrophy (FSHD). FSHD is characterized by a unique genetic lesion, whose discovery has challenged researchers for years, and investigating its fascinating pathophysiology is a field of active research with new hopes of treatment development.   

What are the programs of cell death activated in FSHD? What are the mechanisms of muscle atrophy taking place in the “in vivo” complex microenvironment? How do they contribute to explain FSHD pathophysiology? How can they be tackled? We will go through all these questions studying and deeply characterizing muscle biopsies in the different stages of damage and other patients’ samples.  

During the PhD you will be able to apply and finally master several techniques, ranging from basic histology to molecular biology. You will be working in an internationally renowned centre specialized in genetic neuromuscular diseases combining clinical and basic researchers, giving you the opportunity to interact with several leaders expert in the different aspects of these diseases providing a holistic understanding of muscular dystrophies.

 

How To Apply

To apply for a studentship, you must register and apply through the University’s Apply to Newcastle Portal 

In the ‘Course choice’ tab: 

  • select ‘Postgraduate Research’ in the 'Type of Study' field 
  • select ‘Full Time’ in the ‘Mode of Study’ field 
  • select ‘2023’ in the ‘Year of Entry’ field 
  • enter programme code 8440F in the ‘Course Title’ field 
  • leave the ‘Research Area’ field blank 
  • press ‘Search’ 
  • Select ‘PhD Translational and Clinical Research (FT)’ 
  • Save selection 
  • a ‘Personal Statement’ (this is a mandatory field) - upload a document or write a statement directly in to the application form 
  • the studentship code TC065 in the ‘Studentship/Partnership Reference’ field 

When prompted for how you are providing your research proposal - select ‘Write Proposal’. You should then type in the title of the research project from this advert. You do not need to upload a research proposal.

 

Start Date

January 2024  

Award Duration

The funding covers a three-year PhD.  

Sponsor

Newcastle UniversityFaculty Medical Sciences 

Supervisors

Professor Giorgio TascaTranslational and Clinical Research Institute 

Location
Newcastle, United Kingdom
Job Type
Academia
Employment Type
Full Time
Job Location
On Site
Apply
giorgio.tasca@ncl.ac.uk
https://applyto.newcastle.ac.uk/SignIn?returnUrl=/
Valid Through
18 Apr 2023
Posted On
03 Apr 2023

Organization Information

Newcastle University, Faculty Medical Sciences

https://www.ncl.ac.uk/

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