Photo of Gisèle Bonne

Dr. Gisèle Bonne

Sorbonne Université - Inserm
Paris Cedex 13, France


Introduction

As basic science researcher, I have been working on the analysis of skeletal and cardiac striated muscles in normal and pathologic conditions for more than 25 years.

My first WMS meeting was in 1999 in Antalya, Turkey, where I discovered the original concept of the triple E, mixing basic science and clinical translational research! Since I have attended almost all WMS annual meetings with exception of 3.

I’m member of the World Muscle Society since 2000, member of the executive board since 2010 and Treasurer since 2017. I have greatly enjoyed being part of WMS since all these years and to contribute to its evolution.

I would be happy to continue to bring my expertise and in particular in basic science to further develop the activities of the WMS, in particular to reinforce the continuum from basic science to clinical and translational research and to promote early carreer researchers, gender equity and diversity.

Biography

I completed my PhD thesis in Developmental Physiology in 1994. I got an Inserm position as senior researcher in 1996, and conducted my research program of the genetics and pathophysiology of Emery-Dreifuss Muscular Dystrophy and identified the first mutation of LMNA gene encoding Lamins A/C (Nat Genetics, 1999). My research program has evolved with time and results towards genetics and pathophysiology of Laminopathies and their related disorders and to reach now the genetics and physiopathology of several neuromuscular disorders. My group created 2 knock-in mouse models reproducing LMNA mutations identified in patients (Hum Mol Genet, 2005, 2011, 2013) models that mimic quite well some of the human disease features and thus represent unique tools to test therapeutic strategies. We have developed mutation database (UMD-LMNA) and established laminopathies patient registry (OPALE, Clinicaltrial.gov NCT03058185, tools that are essential for bench-to-bedside translation. I’m currently leading a research team at the Myology Institute (Paris, France) focusing on genetics, pathophysiology and therapeutic approaches of muscle disorders with a special interest on laminopathies and collagen VI related myopathies. I’m coordinating since 2000 the French network of EDMD & other laminopathies. I have been Chair of the French Muscle Society (2015-2019).

Research benchmark: I authored more than 360 peer-reviewed publications. H-index: 59; 12 088 citations (Web of Science)

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